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In contrast, cuproptosis-C1 tumors were characterized by an abundance of T helper cells, central memory T (Tcm) cells, and Th2 cells, alongside elevated expression of immune-checkpoint moleculesa profile that may be associated with immune exhaustion and potentially greater responsiveness to immune-checkpoint blockade (ICB), though this remains to be functionally validated

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Focusing on targets that impeded viral replication with only a small impact on cellular replication (tier-1 targets), we identified 254 potential enzyme targets, of which 158 have already been reported in association with viral proteins

doi:10.1210/en.2014-1653

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